Download e-book for iPad: Adaptive Design Methods in Clinical Trials, Second Edition by Shein-Chung Chow,Mark Chang

By Shein-Chung Chow,Mark Chang

With new statistical and clinical concerns coming up in adaptive scientific trial layout, together with the U.S. FDA’s fresh draft assistance, a brand new variation of 1 of the 1st books at the subject is required. Adaptive layout equipment in scientific Trials, moment Edition displays fresh advancements and regulatory positions at the use of adaptive designs in scientific trials. It unifies the massive and regularly becoming literature and examine actions on regulatory standards, clinical and useful matters, and statistical methodology.

New to the second one Edition
Along with revisions through the textual content, this variation considerably updates the chapters on protocol modification and medical trial simulation to include the most recent alterations. it is usually 5 totally new chapters on two-stage adaptive layout, biomarker adaptive trials, goal medical trials, pattern dimension and gear estimation, and regulatory perspectives.

Following within the culture of its acclaimed predecessor, this moment variation maintains to supply an updated source for medical scientists and researchers in academia, regulatory enterprises, and the pharmaceutical undefined. Written in an intuitive type at a easy mathematical and statistical point, the ebook keeps its sensible method with an emphasis on thoughts through a number of examples and illustrations.

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Adaptive Design Methods in Clinical Trials, Second Edition (Chapman & Hall/CRC Biostatistics Series) by Shein-Chung Chow,Mark Chang

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